International Journal of Biomedical Laboratory Science(IJBLS) Vol. 2, No. 2:1-13
December, 2013
 

CONTENTS

Minireview
► Ethics and Quality Assurancein Biomedical Laboratory Science
Vincent S. Gallicchio, Linda M. Gallicchio
Int. J. Bio. Lab. Sci 2013 2:1-4 【Abstract】 【PDF】
 
Original Articles
► A new product, BioCoolR, to combat free-living amoebae in water
Amir Saeed,Gunnar Sandstrom
Int. J. Bio. Lab. Sci 2013 2:5-8 【Abstract】 【PDF】
 
► Interference between eplerenone and digoxin in an enzyme multiplied immunoassay technique and chemiluminescent immunoassay
Tomoyuki Yamada, Kaoru Suzuki, Kazuhito Ueda, Ken Iguchi, Ryuji Kato, Yoshio Ijiri,Toshiyuki Ikemoto, Masami Nishihara, Tetsuya Hayashi, Kazuhiko Tanaka,Takahiro Katsumata1, Hiroshi Tamai
Int. J. Bio. Lab. Sci 2013 2:9-13 【Abstract】 【PDF】
 

Published 【PDF】

2013 Vol.2. No2

 

Interference between eplerenone and digoxin in an enzyme multiplied immunoassay technique and chemiluminescent immunoassay
Tomoyuki Yamada, Kaoru Suzuki, Kazuhito Ueda, Ken Iguchi, Ryuji Kato, Yoshio Ijiri,Toshiyuki Ikemoto, Masami Nishihara, Tetsuya Hayashi, Kazuhiko Tanaka,Takahiro Katsumata1, Hiroshi Tamai
Int. J. Bio. Lab. Sci  2013  2:9-13 Abstract】 PDF
 

Abstract
Digitalis-like immunoreactive substances (DLISs) have been shown to cross-react with anti-digoxin antibodies. We previously reported that eplerenone, the structure of which is similar to that of digoxin,interfered with digoxin measurements in a fluorescence polarization immunoassay (FPIA), microparticle enzyme immunoassay (MEIA), and affinity column-mediated immunoassay (ACMIA),and also that the extent of interference was different in each assay. Digoxin has a narrow therapeutic window; therefore, it is important to measure its serum concentrations without interference by clinically co-administered drugs. In this study, we performed two additional types of assays (enzyme multiplied immunoassay technique (EMIT) and chemiluminescent immunoassay (CLIA)) to clarify cross-reactivity between eplerenone and anti-digoxin antibodies. Furthermore, we used EMIT and CLIA to measure apparent digoxin concentrations in mixed solutions of eplerenone (1-100 μg/mL) and digoxin (1-3 ng/mL). Eplerenone was not detected as digoxin by EMIT and CLIA in cross-reaction tests. Furthermore, the apparent concentration of digoxin when co-administered with eplerenone was not significantly affected in EMIT and CLIA. These results suggest that EMIT and CLIA may be able to accurately measure serum digoxin concentrations in patients adjunctively receiving eplerenone.
Key words: DLIS, eplerenone, EMIT, CLIA, therapeutic drug monitoring

Ethics and Quality Assurancein Biomedical Laboratory Science
Vincent S. Gallicchio, Linda M. Gallicchio
Int. J. Bio. Lab. Sci  2013  2:1-4 Abstract】 PDF
 

Abstract
The biomedical laboratory science profession and the professionals who work in this field are dedicated to deliver the best possible services to patients because it is essential in the promotion of quality health care. The information generated with the completion of human genome project has and continues to transform human clinical medicine by pinpointing at the molecular level the causes of diseases that heretofore were unknown. In addition, the impact of the human genome project has created the emerging science of biological therapy, meaning future medicines will be tailored
made for every patient each with their own specific diagnosis based upon their own individual genetic blueprint. Thus, as discoveries are made at the bench then tested at the bedside to eventually enter delivery to communities, the revolution of translational medicine is upon us. How will the biomedical laboratory respond to these changes both in terms of the profession as a whole but importantly how each and every laboratory professional addresses these changes that are revolutionizing the practice of the laboratory profession and laboratories in general? To best address these changes will require all laboratory professionals to have a quality sense of ethics, especially as it relates to making good, sound decisions. This quality will be paramount to determining how these changes will be implemented such that the delivery of quality health care to our patients will not be compromised. This paper addresses many of the concerns involved in making sound ethical decisions.
Key words: biomedical laboratory science, ethics, good decision making

A new product, BioCoolR, to combat free-living amoebae in water
Amir Saeed1,Gunnar Sandstrom
Int. J. Bio. Lab. Sci  2013  2:5-8 Abstract】 PDF
 

Abstract
Acanthamoeba is a suitable model to study eukaryotic cells as regards disinfectants, survival and growth. It could be a general model for such studies and can represent several eukaryotic human parasites. In the present study a new disinfectant product BioCoolR was tested for ability to kill Acanthamoeba castellani a free-living amoebae present in the environment. By count of the viable cells 2% of final concentration of BioCoolRsubstance inhibits viability of A castellani.after 1, 2 and 24 hour according to the p value of t-test which was 0.002, 0.049 and 0.001 respectively.
Key words: water, amoeba, parasits

International Journal of Biomedical Laboratory Science(IJBLS) Vol. 2, No. 1:1-30
April, 2013
 

CONTENTS

Minireview
► Role of Cyotkines in Metabolism and Type 2 Diabetes Mellitus
Yung-Luen Shih, Kuo-Ting Ho, Chang-Hui Tsao, Yih-Hsin Chang, Ming-Yuh Shiau, Chien-Ning Huang, Shun-Chun Yang
Int. J. Bio. Lab. Sci 2013 2:1-6 【Abstract】 【PDF】
 
Original Articles
► Improving Quality at the Preanalytical Phase of Blood Sampling: Literature Review
Outi Makitalo, Eeva Liikanen
Int. J. Bio. Lab. Sci 2013 2:7-16 【Abstract】 【PDF】
 
► "Development work thesis" as a Tool for Continuing Professional Education
Eeva Liikanen, Sirkka-Liisa Halimaa, Riitta Lumme, Outi Makitalo, Annikki Railio, Annikki Savolainen
Int. J. Bio. Lab. Sci 2013 2:17-24 【Abstract】 【PDF】
 
► Diagnosis of Tuberculosis by PCR-based Amplification of mpt64 Gene from Peripheral Blood
Shin-Hwar Wu, Cheng-Mao Ho, Jang-Jih Lu
Int. J. Bio. Lab. Sci 2013 2:25-30 【Abstract】 【PDF】
 

Published 【PDF】

2013 Vol.2. No1

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