The Effects of Orthodox Christian Fasting on Blood Coagulation
Maria Liali, Leonidas Mpirintzis, Eleni Vagdatli, Evagelia Pantziarela, Vasiliki Konstantinidou*, Eygenia Limperaki, Georgios Andreadis
Int. J. Bio. Lab. Sci  2015  4:39-43 Abstract】 PDF
 

Abstract
Introduction: Several studies in recent literature refer to the effects of nutrition and religious fasting on blood coagulation. Nevertheless, the influence of Orthodox Christian fasting on blood coagulation has not yet been studied. The aim of this study is to investigate whether the 48 days that Orthodox Christians fast prior to Easter affects blood coagulation. Materials and Methods: The studied sample consisted of 41 volunteers, aged 20-55 years, who fasted and abstained from animal products for 48 days. For each participant, blood samples were collected in sodium citrate tubes before and after the fasting period. Prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen concentration, and the activity of coagulation factor VII (FVII) were measured with an automated coagulation analyzer. Data was analyzed using SPSS v.21 software for Windows. Normality of continuous data was determined. In order to compare the results before and after the fast t-test was applied. A p value < 0.05 was considered statistically significant. Results: At the end of the 48 day fasting period, a statistically significant decrease in APTT (p < 0.001) and FVII activity (p = 0.001) were noted. In contrast, PT increase and fibrinogen concentration decrease were observed, but neither change was statistically significant (p = 0.577 and p = 0.096, respectively). Conclusions: It is possible that blood coagulation is not affected by Orthodox Christian fasting, as the balance between the exogenous and the endogenous coagulation pathways does not change. This fact can be attributed to two possible mechanisms: a) low consumption of animal fatty acids has beneficial effects on the exogenous coagulation pathway, b) the endogenous coagulation pathway appears to show greater activation post-fasting, even the lower fibrinogen levels. The mechanism of this activation is still unknown and needs to be elucidated.
Key words: Orthodox Christian fasting, religious fasting, coagulation, hemostasis

International Journal of Biomedical Laboratory Science(IJBLS) Vol. 4, No. 2:23-39
March, 2016
 

CONTENTS

Original Articles
► Core Competences - A Mixed Methods Study of Biomedical Laboratory Scientists in Norway
Synnøve Hofseth Almås, Atle Ødegård
Int. J. Bio. Lab. Sci 2015 4:23-33 【Abstract】 【PDF】
 
► Hepatitis B, Human Immunodeficiency Virus and Hepatitis C Virus Infections among Marriage Intending Couples in Calabar, Nigeria
Ofonime M. Ogba, Aniekan-Augusta O. Eyo, Ebele B. Edeh, Miriam C. Ogugbue
Int. J. Bio. Lab. Sci 2015 4:33-38 【Abstract】 【PDF】
 
► The Effects of Orthodox Christian Fasting on Blood Coagulation
Maria Liali, Leonidas Mpirintzis, Eleni Vagdatli, Evagelia Pantziarela, Vasiliki Konstantinidou, Eygenia Limperaki, Georgios Andreadis
Int. J. Bio. Lab. Sci 2015 4:39-43 【Abstract】 【PDF】
 

Published 【PDF】

2015 Vol.4 No2

Core Competences - A Mixed Methods Study of Biomedical Laboratory Scientists in Norway
Synnøve Hofseth Almås, Atle Ødegård
Int. J. Bio. Lab. Sci  2015  4:23-33 【Abstract】 【PDF】
 
Abstract
Background: This study describes how a sample of Norwegian biomedical laboratory scientists perceive their profession's core competences.
Method: An explorative sequential mixed method was conducted based on two rounds of data collection and includes qualitative and quantitative data. In a pilot study, seven biomedical laboratory scientists, from a middle-sized and a smaller hospital, contributed in a qualitative research interview. The interviews were transcribed and analyzed. In a main study, a questionnaire containing 36 statements was developed to investigate the biomedical laboratory scientists’ perceptions of their core competences. The questionnaire was forwarded to a random selection of 2000 biomedical laboratory scientists. A total of 587 respondents completed the questionnaire, giving a response rate of 29.3 per cent. Results and conclusion: The results of the interviews showed that biomedical laboratory scientists perceived their core competences as basically related to analyses and the quality of biomedical laboratory work. The data analysis of the responses from the survey revealed seven factors describing core competences in biomedical laboratory processes. The factors include pre-analytic, analytic and post-analytic competence, in addition to co-mentoring skills and collaborative competence.
Key words: quality, analysis, core competence, biomedical laboratory scientist, collaborative competence
Hepatitis B, Human Immunodeficiency Virus and Hepatitis C Virus Infections among Marriage Intending Couples in Calabar, Nigeria
Ofonime M. Ogba, Aniekan-Augusta O. Eyo, Ebele B. Edeh, Miriam C. Ogugbue
Int. J. Bio. Lab. Sci  2015  4:33-38 Abstract】 PDF
 

Abstract
Premarital testing for genotypes, blood group, hepatitis B surface antigen (HBsAg) and human immunodeficiency virus (HIV) is compulsory for marriage intending couples in some faith based organizations in South southern Nigeria. These tests are important for the prevention of genetic disorders and some infectious diseases. Objectives: This prospective study was designed to establish the infection rates of HBV, HIV and HCV among prospective spouses attending marriage counseling in churches in Calabar. Methods: The study ran from January 2010 to December 2014. Informed consent was obtained from the 240 intending couples. Data for demography and medical history were collected through oral interview. Sera from patients were tested for HBsAg with the rapid chromatographic immunoassay one step lateral flow kit (Acumen labs and diagnostic centre, Bangalore, India). Anti HCV was tested with one step lateral flow rapid chromatographic immunoassay (ABON Biopharm). Determine kits (Abbot, Japan) were used for screening subjects for HIV 1/2. Results: Out of the 240 subjects screened, 14(5.8%) were positive for HIV, HBsAg and HCV infection. All the subjects positive for HBV 8(3.3%) were HIV negative, while all the HIV positive subjects were HBV negative. There was no co-infection between HIV and HBV (χ2 = 1.7, p = 0.19). Infection rates peaked at age 26-35 years 10(71.4%) with 4.0% of females positive for HBV. Conclusion: Results from this study may provide some epidemiological evidence for policy making for mandatory premarital testing. A break in transmission of hepatitis B virus infection may occur as a result of vaccination of negative partners.
Key words: HBV, HIV, HCV, infections, Premarital screening

Biochemical Bone Markers in Greek Postmenopausal Women
Marilena Stamouli, Antonia Mourtzikou, Abraham Pouliakis, Anastasios Skliris, Droseri Reppa and Petros Karakitsos
Int. J. Bio. Lab. Sci  2015  4:17-22 Abstract】 PDF
 

Abstract
Introduction: Osteoporosis is a public health problem affecting more than 200 million people worldwide, especially women. The aims of this study were: 1) to measure the serum levels of three bone-specific proteins: osteocalcin (OC), osteopontin (OPN) and osteoprotegerin (OPG) in Greek postmenopausal women and 2) to evaluate correlations between these proteins with age, total serum alkaline phosphatase levels (ALP), serum calcium levels (Ca) and serum C reactive protein levels (CRP).
Materials and Methods: During the study there were recruited 100 postmenopausal women, aged between 45 and 67 years. Samples were analyzed for ALP, Ca and CRP levels respectively on the Olympus AU640 fully automated analyzer and for OC, OPN and OPG with Luminex technology. Results: Eleven patients had high ALP levels, four patients low Ca levels, four high Ca levels and forty seven high CRP levels. Eighty three samples presented OC levels within normal range, four presented lower levels and eleven increased OC levels. Increased OPN or OPG levels were not observed.
Conclusions: The lack of estrogen in postmenopausal women prevents the absorption and utilization of calcium and this constitutes a very important factor in the development of osteoporosis. The findings showed a low positive correlation of OPN with ALP, OPG with age, OPG with ALP and OPG with CRP. Correlations between any of the three bone-specific proteins and calcium levels were not observed. These preliminary results underline the requirement for large-scale population studies in Greek postmenopausal women in order to compare results of this population group with international reference ranges.
Key words: osteocalcin, osteopontin, osteoprotegerin, post menopause, osteoporosis Declaration of Interest: All authors declare that they have no competing interests.

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