Great interest in a Swedish nationally regulated specialist education among biomedical laboratory scientists and biomedical laboratory scientist students
Quttineh M, Heldestad V, Wijkmark T, Rehnberg M, Lillsunde Larsson G
Int. J. Bio. Lab. Sci 2021(10)1:28-35 【Abstract】 【PDF】
 
Abstract

Biomedical laboratory scientists (BLS) work in many different disciplines but one common denominator for all the fields within the profession is the rapid development in biomedicine and the corresponding increase of advanced technology. A nationally regulated specialist training for BLS is a way for the profession to gain advanced skills and to create career opportunities. From a larger study set, the aims of this sub-study were to investigate BLS student’s and professional’s view on education, choice of workplace, career development, advanced studies and a potential nationally regulated specialist training program. Two surveys were designed using webbenkater.com. The surveys were sent to BLS student members (n=483) and professional members (n=2083) of The Swedish Institute of Biomedical Laboratory Science (IBL), the professional organization of BLS´s in Sweden. Response rate was 57% (276/483) for the student sub-survey and 44% (n=923/2083) for the professional sub-survey. Students from all semesters (1-6, n=272) were represented, with a majority from semester 2, 4 and 6. Top reasons for choosing the BLS education were; easy to get a job (65%), stimulating work tasks (59%) and a good education for further studies (39%). A majority of the students planned for further advanced academic studies (64%) and 54% percent were interested in a potential nationally regulated specialist training. Among professionals, 21% stated there were explicit career paths at their workplace. The individual interest for a potential nationally regulated specialist training was 53% and most responders (93%) stated a need for such an education in Sweden. Among IBL members, there is great interest in a nationally regulated specialized training among both future and present professionals in Sweden. In relation to a future shortage, we also show that in order to attract students to BLS training, we need to be able to offer advanced training as well.

Key words: Medical Laboratory Personnel, Medical Laboratory Science, Education.
 
Research Article – Expression of the Forssman antigen in gastrointestinal cancer
Tiago Silva, Diana Martins, Paulo Teixeira, Cristiana Mourato, Rúben Nunes, Carolina Melo, Clara Rocha, Simone Oliveira, Inês Mónica, Lucília Conceição, Daniel Almeida, Inês Oliveira, Fernando Mendes

Int. J. Bio. Lab. Sci 2021(10)1:21-27 【Abstract】 【PDF】 

Abstract

Forssman (FORS) system is a new histo-blood group system with only one antigen. This Forssman (FORS1) antigen is expressed in erythrocytes, body fluids, several cells types and organs according to the species involved. Humans are Forssman negative, so the occurrence of antibodies Anti- FORS1 is highly common. However, there are individuals that are Forssman positive. Several studies suggest that the FORS1 antigen might have a key role in carcinogenesis. In this study, the aim was to determine FORS1 antigen expression in gastrointestinal cancer samples and compare the expression in normal and neoplastic tissue.

The expression of FORS1 antigen was analyzed using immunohistochemistry on gastrointestinal tumor and normal samples. The present study compared FORS1 expression in normal and tumor tissues, and the associated FORS1 expression pattern of differentiation with the therapeutic regimen.

The results demonstrated that from the 12 cases studied, 8 cases presented weak expression, 2 cases presented moderate expression of FORS1 antigen and 5 showed strong expression of FORS1 antigen in the cytoplasm of tumor cells. The results demonstrated that the intensity and extension of immunostaining differ according to the differentiation profile, suggesting that areas with a well-differentiated tumor showed higher expression of FORS1 antigen, whereas poorly differentiated areas presented less expression of FORS1 antigen. Samples from patients who performed chemotherapy regimens showed less Forssman expression, compared to patients who underwent surgery, suggesting that FORS1 antigen may have a relevant role in gastrointestinal carcinogenesis.

 
Key words: Forssman Antigen, gastrointestinal cancer, immunohistochemistry, antibodies.
International Journal of Biomedical Laboratory Science (IJBLS) Vol. 10, No. 1:1-35
April, 2021  【PDF】

 

CONTENTS

Editorials
► International Journal of Biomedical Laboratory Science (IJBLS) - Quality Information, Peer-reviewed and Relevant Knowledge
Patricia Tille
Int. J. Bio. Lab. Sci 2021(10)1:3 【PDF】
 
Have your talent recognized, publish your research
Alan Wainwright
Int. J. Bio. Lab. Sci 2021(10)1:4 【PDF】
 
► Laboratory spotlight – Healthcare and Biomedical Laboratory Science Practice in the Philippines
Evangeline R. Castillo, Rommel F. Saceda
Int. J. Bio. Lab. Sci 2021(10)1:5-7 【PDF】

 

Brief Communication
► World Health Organization Essential in vitro Diagnostics 2020
Marie Culliton
Int. J. Bio. Lab. Sci 2021(10)1:8-11 【PDF】

 

Original Research Articles
Rapid screening model for identifying patients with suspected intravascular hemolysis to improve patient care and reduce sample rejection rates in clinical chemistry
Gabriel Garang Pioth, Gay Janet Davis, Uba Nwose, Philip Bwititi
Int. J. Bio. Lab. Sci 2021(10)1:12-20  【Abstract】 【PDF】
 
Research Article – Expression of the Forssman antigen in gastrointestinal cancer
Tiago Silva, Diana Martins, Paulo Teixeira, Cristiana Mourato, Rúben Nunes, Carolina Melo, Clara Rocha, Simone Oliveira, Inês Mónica, Lucília Conceição, Daniel Almeida, Inês Oliveira, Fernando Mendes
Int. J. Bio. Lab. Sci 2021(10)1:21-27【Abstract】 【PDF】
 
Research Article – Great interest in a Swedish nationally regulated specialist education among biomedical laboratory scientists and biomedical laboratory scientist students
Quttineh M, Heldestad V, Wijkmark T, Rehnberg M, Lillsunde Larsson G
Int. J. Bio. Lab. Sci 2021(10)1:28-35 【Abstract】 【PDF】
 
 

 

Published 【PDF】

2020 Vol.9. No1

 

 

Rapid screening model for identifying patients with suspected intravascular hemolysis to improve patient care and reduce sample rejection rates in clinical chemistry
Gabriel Garang Pioth, Gay Janet Davis, Uba Nwose, Philip Bwititi

Int. J. Bio. Lab. Sci 2021(10)1:12-20 【Abstract】 【PDF】 

Abstract
The importance of developing a rapid screening model is critical for identifying patients with intravascular hemolysis to improve patient care and reduce sample rejection rates. Specimen hemolysis is a leading cause of spurious test results in clinical chemistry. Intravascular hemolysis releases cell-free hemoglobin into the serum and haptoglobin irreversibly binds hemoglobin to form a hemoglobin-haptoglobin complex, which is cleared in the circulation by the monocyte-macrophage scavenger receptor CD163 in the liver and spleen. The depleted serum haptoglobin in a hemolyzed sample is used to diagnose intravascular hemolysis. However, haptoglobin testing may take hours or days to confirm intravascular hemolysis. The aim of this study was to investigate the relationship between intravascular markers of hemolysis and haptoglobin in hemolyzed specimens. This study retrospectively mined archived data from the laboratory database between February 2017 and February 2018 from patients 6 months of age and above. The Statistical Package for Social Science was used for data analysis. The partial plot results showed a strong relationship between hemolysis markers and haptoglobin levels. Multiple regression models that predict serum haptoglobin levels in intravascularly hemolyzed samples were analyzed. Although the results showed a strong relationship between dependent and independent variables, the data did not demonstrate a clinically significant relationship or establish cause and effect. The use of a larger sample size along with adequate controls in preanalytical, analytical, biological and environmental variables would likely improve the clinical significance of the model. With proper modifications and validations, this model has the potential to provide a rough estimate of the haptoglobin levels and reduce cost as well as sample rejection rates. Due to the numerous hemolytic diseases, this model could be used to direct the clinicians to select the appropriate test for diagnosis of intravascular hemolysis.
 
Key words: haptoglobin, intravascular hemolysis, extravascular hemolysis, turnaround time, in vivo hemolysis, in vitro hemolysis, hemolysis markers.

Statistics

Articles View Hits
561685